Loredano was immediately promoted to master glassmaker. In 1964 he opened his own furnace in collaboration with his brothers Mirco and Dino, who would always be at his side from then on. Rosin also worked with master Ermanno Nason.

But the great turning point in his career came in 1965 when he met Egidio Costantini, who asked him to collaborate with Fucina degli Angeli on glass works designed or conceived by the most important national and international artists of the contemporary art world of the time: Picasso, Chagall, Ernst, Arp, Kokoshka and Cocteau and Italian artists such as Fontana, Licata, Guidi and Guttuso.

Until August 1974, Rosin produced the works of these great artists in the furnaces and increasingly honed his natural technical skill in working with solid glass.

1975, together with his brother Dino, he finally founded the "Vetreria Artistica Loredano Rosin" in which he was free to create glass sculptures of great beauty, rediscovering techniques and types of glass whose use had long been lost, to name but one: chalcedony.

Alternated with crystal, Rosin's chalcedony (obtained by adding silver nitrate to the melting mass to create smooth streaks in the glass, reproducing the effects we see in some hard stones, particularly ribbed agate) soon became the basis on which to create extraordinary works, completely rounded, characterised by plastic and soft shapes that immediately attracted the public's interest, raising him to the top of Murano's artistic production.

In 1985 Loredano Rosin began a series of highly successful international exhibitions: first in the United States, particularly in Philadelphia, where his first solo exhibition of new works at the Dorothy Lerner Gallery was an extraordinary success, followed the following year (1986) by another exhibition at the Adele Rosen Gallery in Santa Barbara, California, and then another in London at Knightsbridge Interiors. In 1987 he exhibited in Japan, in Tokyo

In 1989 Loredano Rosin was chosen to represent Murano's artistic production at the "International Glass" event in conjunction with the 19th Annual Symposium of the Glass Art Society in Toronto, Canada; in the same year he took his sculptural works to Norway, to be exhibited at the "Murano Glass: 1400-1989" exhibition at the Kunstindustrimuseet in Oslo.

Until the early 1990s, Loredano Rosin's success seemed unstoppable, characterised by continuous recognition and national and international awards.